There is no doubt that a .22 can kill just about anything if the bullet enters the brain. The tough part is getting through it to do it. Most everyone wants the hogs to be controlled or totally eliminated but in my opinion that will never happen. They breed so fast & and can have up to eight piglets in each litter. They have several litters each year so just do the math & you can see what a bad problem they can become in just a few years.