I think it depends on the manufacturer.
There are certainly .22 LR conversion uppers that work on standard AR lower receivers... there are even .22LR bolt/mag conversions that work in standard AR rifles...
I believe the key would hinge on the trigger/hammer mechanism in the lower of the dedicate .22 LR rifle you purchase as to whether or not that trigger group would work with a .223/5.56 bolt carrier group.
Good Luck
Tack