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Yes and possibly.

Anything that crawls, walks, runs, swims, or flies is edible. I have been is some pretty remote parts of the world, and you would be amazed at what people will eat, especially when they are hungry. That is why I call the animal rights movement a rich man's sport.

The vast majority of diseases can be cooked out of meat. The only ones I can think of that cannot are the transmissible spongiform encephalopathies, the most common of which results in Creutzfeldt-Jakob disease. Fortunately, there are no known cases of rodents transmitting this disease via ingestion.
 
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