Boy, you don't want to do TOO much there do you?
Okay, first off, anything can be done if you want to throw enough money at it.
That said, I don't believe this is an operation you are going to want to undertake because of the expense versus just buying a new rifle in .22 Hornet.
What is the twist rate on your rifle? Because conventional wisdom is a 1:14 is "factory ideal" for the .22 Hornet
If you don't have that sort of twist rate, it's kind of a mute point to rechamber a rifle in a rate that will underspin, or over spin, your desired caliber.
That being said, converting from a rimfire to a centerfire is something I have never done, or seen done, so I just don't know what work you would have to do on the action itself to get it to work, but my guess, more than you want to do.
As far as dimensionally, it would appear on the surface that you could rechamber the barrel, but the action would be a WHOLE different story all together....
JD