New or Old? what do you want to do?
Id had a few, depends what you want to do with it and your personal prefrence.
Id suggest getting exactly what you want after trying several diffrent types.
for fun fun fun (wherd my pay check go?) I'd get a Calico 110 or a Tec-22.
for plinking a Browning Buck Mark, or a older Colt or any of the Ruger Mk series or a single six revolver.
My all time fave .22 plinker was shooting my friends 1995 Colt .22 automatic, you dont see them much now but they are worth it if you find one, very much like the late 1960's High Standard semi's.
I have a couple older High Standard's one is a Semi and one revolver (Victor and a Sentinel)
My fave revolver is a 4" stainless taurus 941 revolver (.22mag after market grips and wolf spring kit) thats really grown on me that gets allot more use than the old worn 3" HS Sentinel Mk IV.
the hot ones for 2013 are the Ruger SR22P, 22/45 lite, S&W M&P22,Taurus Tracker 922, Walther P22, Sig/GSG 1911-22, Sig Mosquito, Beretta Neo, Browning Buckmark, Charter Arms .22LR, Phoniex HP 22.