I never liked the fact that Rugers are investment cast as opposed to forged steel like Smiths and Colts; but that's really a theoretical objection. It's hard to imagine a stronger gun. I've never heard of a Ruger revolver failing.
I would not give it a seconds thought, 9 times out of 10 a revolver gets mutilated buy an inexperienced hand loader not buy factory ammo, the only exception would be using modern ammo in an older or antique firearm, for obvious reasons.I bought some .45 colt ammo for hunting. the box warning read use only in Ruger, Colt Anaconda and Thompson center. Note no S&W.