I'm looking to get a .45 as a car/home gun. This will be my 1st pistol to own but not my first to shoot. I've shot a few .45's and didn't find the recoil to be impressive at all. I've also spent the last 12 years getting to know the Beretta 92 9mm and I really love that gun. If they made it in .45 I wouldn't be writing this! The only thing I don't love about it is the lack of lefty friendliness. I'd like my new gun to be lefty friendly, full sized, hold 10 or more rounds, polymer framed and cost less than $600. I have pretty big hands so grip size ins't an issue. I've had my eye on a few already, and held a couple at a local shop. I've shot the USP45 and a Ruger 45, P90 I think. Both were good shooters, but no lefty controls. The USP had right handed molded grip and I was still pulling off sub 4" groups at 15 yards. The XD45, 24/7, P250, HK45 and M&P45 are the ones that I've actually handled. I liked the M&P, but an excop friend of mine said his partner had 2 different models that kept jamming on him. I've also heard several cases on gundirectory about them jamming in various ways. That kind of makes me want to steer away from it. I've also heard a lot of positive feedback too, so I'm on the fence. The 24/7 felt nice, but the slide release was so stiff I nearly dislocated my thumb working it. (and its on the right handed side) Other than that, I liked it a lot. It's really light. The XD was nice in the same way. I was very impressed with the new modular P250. It felt great and had a great trigger, but is it like a leatherman multi-tool. Really handy, but no where near as good as actual pliers and screwdrivers....? The HK45 felt like a dream! But its $1200 so it's out. I'm really interested in the FNP45 and the PX4 .45. No one around here has one so I haven't been able to hold one. Please tell me what you think and why. If I'm misled somewhere let me know. I'm big boy, so I can take it.