Hey, if you have your black powder gun figured out, why not. At one time all game fell prey to BP or arrows. I admire anyone that is proficient with BP weapons. I have worked with a Knight inline off (mostly off) and on for the last ten years or so and have yet to master loads and groupings. Yote calling would be a hoot with a accurate BP. Myself, I would have to call Charlie in close enough, that I could club him with my Knight.
I don't have a fancy ML just a .50 CVA Optima. But I can get groups touching at 50 yards, even when using 295 Powerbelts and 100 grains with Triple Seven
pellets. I will try 225 grain Powerbelts with 130 grains in pellets.
By the end of the summer I will probably graduate to Blackhorn 209 loose and maybe other bullets.
I love my Knight. Extremely accurate and reliable. I use nothing heavier than 240 gr and 130 gr powder. If I were to hunt yotes with it, I would use 220 gr bullet and 130 gr powder. Any accurate inline should be good to 200 yds with that set-up, imo. I sight in at 1" high at 100 yds. If shooting to 200 yds, I expect 4-5" drop with that set-up. No reason to use 295 gr bullet for deer either. There is plenty of energy with a 240 gr bullet and 130 gr powder. Heck, I have dropped deer (big Southern Ohio deer) at 'bout 100 yds with 220 gr bullet and 100 gr powder. Go poly tipped expanding bullet, and it will bring 'em down.
Too many bp shooters think they need 300 gr bullets and 150 gr powder. Overkill!