You are right. Shot placement is key when using lethal force, you can have the most advantageous handgun with the most velocity and size but if you don't hit in the right spot you are still in trouble.I'd probasbly say the 500 S&W too.
However, shot placement counts for more I think
I believe the .25 acp out of the Raven MP-25 has top honors. Lots and lots of shootings.
Out of those....all of them. But the most lethal one would be the one you can hit the target with. (proper shot placement is what matters)What is the most lethal handgun round out of the following in your opinion (or if you can prove it with facts thats better?)