I have large strong hands and still find it very difficult to use the slide release with my left index finger. That seems to be my only option being left handed. I have ran about 1,000 rds through my xd45. I have been doing some dry practice drills. I am hoping my finger will become more accustomed and perhaps a little stronger. I am also hoping as the pistol breaks in perhaps it will lossen up a bit. The people at the gun shop say it's fine although he could not use it with his left index finger. He said it was because he was not left handed. Any help out there would be appreciated.