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For a good defense load, I use 125 JHP over a max charge of H110.

It chronos 1625 FPS from my 6 inch security six.

When most LE carried the .357 revolvers, the Federal 125 JHP was pretty much the standard.
 

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Unfortunately, there is no full power .357 load that will not be "brutal" in a SP101.

Since this is a defensive type weapon, I would focus on 125 grain loads. 158 are better suited for hunting.

H110 for loading is a good powder. I use it for all of my .357 and .44 magnum loads regardless of bullet weight.

The mods have asked that I do not post my primer choice so I'll leave that to others.
 
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