Sure.
Of course, in order for a person to be effective in an ugly situation then one has to be competent and capable with the chosen gun. Personally, I prefer having a greater number of rounds, but there's no denying the suitability of typical revolver calibers for defensive use. Every gun has pros and cons. Revolvers can be quite effective.
Have had a S&W 442 Airweight .38, some years ago. Much prefer a gun to have some heft, and the Airweight line-up are quite light so can be a handful for many people to fire accurately. My all-time favorite revolver is the Ruger Redhawk KRH-444 (or 5044) .44mag revolver in 4" barrel, for its balance and heft, though it's fairly stout for arrying all day every day. But, everyone's different.
If considering a specific handgun for purchase, definitely check your local FFL gun shop along with the list of certified/approved handguns at the state AG's website (in your other thread
'New to California'). Lots of handguns you'll find and drool over won't be on California's list. Bummer, but that's the way it is in the state.