Making any modifications to your firearm in the action area leaves you open to weakining the action and having a bad failure. Just because they do not produce the psi of some centerfire round does not mean you can not blow one up.
I would sugest learning how to field strip the firearm to clean it.
No firearm I know of needs anything drilled in the action for clean out.
If it is for using a cleaning rod just clean from the muzzle taking care not to damage the muzzle. There is no way a patch and a brass jag will make barrel steal move. but you can nick it.
I think the reference may be to 10/22 receivers that have been drilled to run a rod from the chamber end. I have seen custom shops do this and some non Ruger receivers have this provision. I would not do it on my own to a factory receiver. I agree with cpttango30. CAREFULLY clean with a brass rod/ jag from the muzzle, and even get a plastic guide.
Another option is to carefully run the cleaning rod down the barrel thru the breech, attach the brush and pull it thru. You can hold the brush with needle nose pliers if you have meat hooks like me. If you are careful there is no need to go from the breech end. Unless you have a high dollar Anschutz or something, I would not sweat it.
I'm assuming it's a 10/22. You can use a bore snake w/o having to drill a hole. If you still want to use a cleaning rod do a search here www.rimfirecentral.com & you'll find the procedure to do it. The receiver is aluminum or a similar alloy so it's pretty easy to drill.
If it is a 10/22 then just take the barrel off the reciever. The only thing holding the barrel to the reciever is two hex bolts. unscrew them and pull the barrel off then you do not have to worry about moding the action or hurting the muzzle crown.
What I have done on all my 10/22s is to take the stock off and take all the guts out of the receiver, with the barrel still attached take a flash light and place it on the end of the barrel so the light will shine down the bore. Mark where the light hits on the back of the receiver. Measure from center of the mark to the OUTSIDE edge of the receiver and do the same for bottom of the receiver. Take you measurements and transfer your center mark for the hole to the outside of the back of the receiver. Clamp the receiver in a vise, carefully as it is aluminum, and drill your hole using a bit that is a little larger than the diameter of the bore. If your hole is not perfectly centered don't worry about it, you shouldn't be puting anything down your barrel that will scratch or gouge it anyways.