I always see heated debates around the interwebs about what is the best caliber for personal defense.Many answer with larger calibers like .45 ,.357,etc. But with someone like me,it isn't that easy.I had an accident in my teens and broke both my wrists so even today they still bother me with pain.The one caliber I can comfortably handle in a self defense gun without agonizing pain is a .380.But that of course depends on the gun and the size and weight of the gun.In a 9mm,firing a Glock 17-19 and Beretta 92 FS is very tolerable,but firing a 9mm in say a Kel-Tec PF9,P11,and LC9 is torture.The smallest pocket 9mms I can tolerate for self defense and not during a 100 round range session is the Beretta Nano,and Glock 26.In a .380,the Ruger LCP and Kel-Tec P3AT were agonizing,but the S&W Bodyguard was tolerable,the best ones that were very manageable and comfortable to shoot were the Bersa .380,Walther PPK/S,and Beretta 84F. I also have tried .38SPL revolvers.S&W Chief's Special snubby was the best,the Taurus 85 was kinda tolerable,but a bit painful,but the Ruger LCR,OUCH! I know there are still many compact and concealable pistols for concealed carry I have yet to try that may be better than ones I have tried.And these were all fired using standard pressure non +P FMJ and JHP ammo. The last large caliber I fired in a concealable size was a Glock 30 and it almost jumped out of my hands.Even the full framed Glock 21 was not very pleasant to shoot.A friend has told me I should try a 1911 so I may try one as I have never fired a 1911 before,nor am I very familiar with them. I do work out to try strengthening my wrists,and it does help. Anyone else physically limited?Any advice would be gladly taken.