Or even health issues. Let's face it folks, it's more than just hormonal changes that can affect that aspect of a relationship. Certain medical conditions can make the affects of such things a thousand times worse, or can leave one with a lack of energy, interest, or enthusiasm for activities they once enjoyed far more. And no one feels particularly attractive or sexy when seriously ill. Sudden traumatic injury can also have such an affect. Both are things I know for a fact. On the change of life, illness enhancements, my mother was a diabetic when she went through menopause. And yes, just as it is with the normal cycle up to that point, elevated blood sugar does not help when that time comes around. One of the signs most have that it is up, is a far shorter temper. I still miss her, and still love her dearly, but, when even the dog decides it's time to run to the garage with you, that says something. I also dated a woman who has to have a hysterectomy at age 26, who even after fully healing up, had close to no interest in sex for about a year afterwards. It wasn't a lack of urges, but, as she put it, you don't feel the same afterwards, you don't feel complete, and you find yourself less attractive as a result. and she and I both agrre that it also may have had to do with a couple other factors, as the then boyfriend had been cheating on her, even on the day of the surgery, and she had gone through almost a year of chemo and radiation prior to said procedure. And here's one to also consider, that most don't know. As men are visual creatures when it comes to being turned on, a severe eye injury, such as losing the sight in one of both, can also be a mental trigger for erectile dysfunction. As can certain meds to treat high blood pressure (Part of the reason things like Viagra and Cialis work is by elevating one's BP) and other medical issues, can also have the same affect. Sex should be an enhancement to a healthy relations, but it can never be the sloe basis of one, as once the thrill is gone, and the fire burns out, so does the relationship.