You might want to break it in first.
Then get small amounts of various kinds, then take it to the range and test it. And by "test," I mean take notes. Because otherwise you may have trouble remembering which brand hiccupped in which gun (though hopefully it'll all feed well in every gun). Printed paper targets often have a place to fill in information, but even without anything provided, you can still write pertinent information like the gun you used, distance, ammo (brand, grain weight, etc.). Then you can take the targets home and compare them at your leisure if you like. Personally, I have taken to photographing the targets (use a Sharpie and write big) so I don't need to carry the targets home.
You'll also want to compare point of aim vs. point of impact between self-defense and practice loads. It'll be nice to be able to practice with target rounds that will hit the same place as your defense rounds.
What a great excuse to shoot a lot of rounds through some fine guns!