My wife and I both have osteoarthritis. She doesn't shoot often and even then, she only shoots .38's in her S&W model 60.
I just shoot whatever I want and ignore any discomfort. I have to, it's in my man contract
We both take OsteoBiflex and it really helps with joint pain. It's MSM, Chondroitin and Glucosomine. I believe it has SAMe in it as well. It's a bit expensive, but we generally find it on sale.
For pain, we either take Ibuprofin 800's or Aleve.