Without trying to start a mudslinging contest, I would advise against Glaser Safety Slugs or other similar ammunition like MagSafe. Others may disagree, but when given a choice in handgun ammunition I will opt for the larger, heavier bullet.
I tend to believe the most important factors for self defense handgun ammunition are permanent wound cavity and penetration. To quote the FBI, "the bullet must pass through large, blood bearing organs and be of sufficient diameter to promote rapid bleeding."
I would recommend a quality self defense round in the 155-180 grain variety. Corbon DPX, Speer Gold Dot, and Winchester Ranger are all excellent choices. As previously mentioned, spend a little money to shoot at least one box of your chosen ammunition to make sure your firearm will feed it reliably.
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