glock 22 grip reduction and crimson trace grips
 

I have a glock 22 and i want to reduce the grip and stipple it to fit my hands better. My question is how much can I actually reduce it and still have the laser fit properly?

Have you already bought the Crimson? I say that because it sounds like the Lazermax guide rod setup might be a better alternative in your case.

Yes it was already on the gun when I got it.