The 10mm is sort of a beast. I would never recommend it to a new shooter and even some experienced ones don't care for it. The one exception here is a nice all steel 5" 1911 in 10mm... that's just nice.
Out of the two I personally prefer the 22 for the thinner frame... you will be much happier if you ever want to conceal it.
On the caliber debate, the more data we gather, the more it looks like it doesn't matter much between the larger calibers (9mm and above). What does matter is capacity since you're probably not going to be at the top of your abilities under extreme stress.