A 22 is an extremely deadly round, most people don't realize how deadly they really are! I heard a guy in a gunshot one time say "just a little 22". If memory serves me correctly, I think there were more people murdered with a 22 a few years back than any other cartridge...I may be mistaken though. But like everyone has said, just because a 22 can kill a buffalo does not mean you should use it to hunt buffalo. Leave the 22 in the safe unless you're going after small game or plinking.
Did I do good all you ftf old timers???
Sorry, I couldn't resist :-)