As mentioned above, yes, you can and no, you don't have to worry if your trajectory is high. I would have some concern if you shoot on low limbs about ricochets, just use common sense and make sure of your background.
I used to use a Ruger Single-Six with iron sights to harvest squirrel in East TX, using standard velocity .22 long rifle cartridges. Stay away from the hyper velocity and HP stuff, too messy-ruins meat.
Love to eat squirrel and dumplings!