I'm sure there alot more rodents than snakes, and they can live a few weeks off one small mouse, so I would just let them do there job, they have there place in the system, don't disrupt the balance, I think it is wasteful, to kill something for no good reason at all, However if for what ever reason you feel you must carry out your plan, I would have to say a shotgun would be the safe way to go, I tried eating a rattlesnake down in florida about 10 years ago and I must say it was Great!!! I don't know if they all tast the same, I'm assuming so, if you kill them, you may want to try it, the lady that cooked the raddlesnake I got some of just cut off its head thats were all the poison is and striped the skin right off like knowbody's business from there she rinsed it off and and layed strips of bacon in tinfoil along with Mr. Snake, and cooked it at 350 for 20 minuts,outstanding!!! Try it, It dose not tast like chicken.
If you run your just going to die tired!!!