I've only ever shot 1 deer in the shoulder. This was 3 years ago on what turned out to be my last hunt with my father before he passed.
A white tail doe broke cover into the field we were watching. Her speed and pattern left no doubt she was being pursued by a HOT buck. Sure enough, he broke cover as well, 220 yards out, came straight at us for approx 20 to 30 yards, then took a hard left giving me a full side view.
Unfortunately he was still chasing the doe, doing that half/run half/gallop thing where they're literally bouncing forward, changing elevation by 24 to 30 inches each time there feet hit the ground.
The saving grace of this is that the neck, shoulder, and front legs are pretty much perpendicular taking elevation out of the equation so I put the cross hairs on the top of his shoulder and tracked him right through my trigger squeeze.
The round hit hard but did not take him off his feet, he scampered about 50 yards, stumbled back word until his hind quarters gave out and pointed his nose at the sky just before falling over dead.
The 150 gr. Remington Core Lock punched through near shoulder, took both lungs, and lodged in the far shoulder, stopped by bone, and still had 90% of it's mass intact.