I take Whitetail every year with a SS Ruger Super Blackhawk in .44 mag. I have a non-magnifying "red dot" type sight (OneV) mounted on it. I've had this setup for quire some time and I'm not sure the OneV is still manufactured. It is an adjustable brightness red dot 'reflex' type.
The nice thing about the OneV is the lack of parallax. Where the red dot is, the impact is. I don't unload on game over 100 yards without a rest. I have taken most of my venison at ranges under 50 yards. Some running, most standing.
The older I get the more hesitant I am to drop the hammer on anything. I'm at the point now that killing a deer is just making a job for myself. The biggest part of hunting is now the simple and quiet joy of interacting with nature.
Actually that's mostly BS - I like making the one-shot kills with the .44 and the beanfield/pipeline shots with the 7mm STW. Especially since I'm using loads I worked up myself. I just mark the location and call one of the younger guys in camp to come 'help'.
And yes, communing with nature is still a rewarding part of the experience. But so is making that 40 acre shot!