Well I have to agree with stalkingbear. I know of nothing a Mathews will not take.
Although, for up to 200 yard shots for big game I choose my good ol' 7mm08
I have shot 2 elk this year alone at 150 to 200yards and dropped them in there tracks. Yes they were very well placed shots..head shots.
Yet for long range take down I will have to go with a .338 lapua or .308.
I suppose it is whatever you have sighted in that makes a kill.