I have shot several deer in the shoulder, using .270, .280 and .308 calibers and all deer expired quickly. I would not recommend a shoulder shot with lighter weight bullets, .223, .22-250, .243, etc.
Not enough meat on a deer's shoulder to fret over.
However, your heart / lung shot is also very effective. Always take the best, ethical shot presented when hunting, heart / lung, shoulder or neck.
Last edited by Gatoragn; 09-14-2011 at 12:33 AM.