Say what you want about any caliber, it is all in bullet placement in most cases. I am not saying you can take A Bear with A 22lr. I have taken deer, pigs out to 300 yards give or take, with A 243 loaded with 100gr sp powered with 42gr of 4831 or 34gr of 3031 depending on what I have. Both will shoot in the same hole at 100 yds. I can see A place for the 300 mags but no where I hunt. I want to gut & cut up myself after shooting the animal. As some one said to many hunters try to make up for bad marksmanship by using A bigger gun. Now if I want to shoot A 1000 or so yards I will break out the 338 Lapua & get er done!!!