Top quality HV solids for pistol and HP for rifles. A 36 grain Mini Mag HP will penetrate 3 pieces of cloth and 13+" of ballistic gel at 30 yards while expanding to almost double when fired from a rifle. Most HP will not expand in the velocities obtained in short barrels and will not penetrate as well as the solids. Stingers and Velocitors are the exceptions but the Stinger is only 32 grains while the Velocitor is 40grains. Some semi autos have problems with the hyper velocity rounds. A revolver would be a safer bet as you dont have to clear a dud. http://www.ballisticsbytheinch.com/22.html
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If you're going to use a 22 for SD shoot CCI mini mags round nose. The hollow points might look good in ballistic gelatin but they unroll like sheet metal when they hit a real bone. A round nose will go right through a 200 LB buck's shoulder blades and exit. A hollow point will not even get close, even a stinger. I have shot coyotes several times with stingers. I can only estimate I have never done a study. Only one out of three stingers go all the way through a 35 LB coyote. A would estimate two of three round nose mini mags will leave an exit wound.
"I do not aim with my hand; I aim with my eye. He who aims with his hand has forgotten the face of his father.
I do not shoot with my hand; I shoot with my mind. He who shoots with his hand has forgotten the face of his father.
I do not kill with my gun; I kill with my heart. He who kills with his gun has forgotten the face of his father."