Would you go into a pen with a 150# wild hog with your .22 and expect to stop its charges?
If you can afford a more robust caliber, do it.
If all you have is the .22, then Stinger (if it can be used in your handgun per manufacturer).
"A well regulated Militia, being necessary to the security of a free State, the right of the people to keep and bear Arms, shall not be infringed."
Life Member NRA
Life Member NAHC
Former President of the ECPT