The powder may have the wrong burn rate needed for that cartridge. It may also not produce enough pressure in that cartridge to get the velocity needed or it may build up to much pressure causing half of your face to become separated from your other half.
There is a program that if it can be done safe will give you safe loads for a verity of powders that are not normally loaded in your specific cartridge. I have never used this software but I know plenty of people who use it.
quickload quicktarget software