My dad used the old Hercules (now Alliant) trifecta of Bullseye, Unique and 2400 for decades. Those three powders will cover most handgun needs quite well. It's where I started and one could still do much worse, even with all the new stuff out there. Locally, Alliant powders have the advantage of being noticeably cheaper than many alternatives as well.
MSgt, USAF, Retired
NRA Life Member
The hardest thing to explain is the glaringly evident which everybody had decided not to see. - Ayn Rand