Only with the two legged kind of snakes....
Long ago, I got my first .22 revolver. A High Standard Double 9.
It came with a lot of ammo and amongst was a brick of .22 bird shot rounds.
Out of those 500 rounds, one kill was made. I was so amazed I skinned the little bird to see what actually did it in.
One pellet. One of the #12 shot actually hit it in the back of the head and kilt the poor chi-chi.
I haven't bought any shot cartridges since. In a rifled barrel they just spread to fast to be effective.
Besides, that's what a shotgun is for. Shot.
But that S&W Governor sure sounds tempting.