The 357 Sig takes bullets in 9mm diameters rather than 357 mag and, that's where the deferences end for me. Other than that I would have to say it is like shooting and handling a semi-auto 357 mag. Even the baby Glocks I have shot in this chambering are manageable, about like shooting a snub nose 357 revolver. In defense loadings I have heard about over penetration in gel although, who is to say that will mean anything in real life. Just my opinion but, you may want to shoot one first to help with your decision.