There are different chokes that cause different patterns. Different ammunition patterns differently. Like winchester ammo to remington. best advice I can say is get your desired round and hit the range. In a home defense situation your not going to be shooting 50 yards. Go with 7 to 10 yards. I don't know how many ranges will let you shoot spread shots at 50 yards.
Remington 870 12 Ga. Supermag
Springfield XDS .45acp