What kind of area do you live in? Rural, Apartment, Farmhouse?
Do you live alone? Is overpenetration an issue?
Heck, this question is like going on a boating forum and asking "what is the best anchor?"
FWIW: I live in a semi-rural area, and have Federal 12gauge 3" OO Buck Magnum 15 pellets, loaded in my Winchester Model 1300, with 5 shells of Winchester PDX1 Defender, riding in a soft sidesaddle on the stock.
The sticky about fighting shotguns at the top of this forum is a good read, and can give you a good idea of the pros and cons of different HD shotgun configurations.