Truthfully, you are comparing apples & oranges as they are two totally different systems that were designed for different purposes.
The bottom line is the 10/22 is a rifle while the PLR is a pistol. I have a PLR-16 (the 22's big brother) and essentially it's a SBR designed for close in shooting and/or personal protection and the 22 version is basically the same. OTOH, the Ruger is a rife, built for target shooting and hunting with accuracy at long (relatively) ranges. Probably the best compromise between both guns is something like S&W's M&P 15-22. FWIW, I have an M&P 15-22 and REALLY like it's versatility.
"... Americans... we want a safe home, to keep the money we make and shoot bad guys." -- Denny Crane