Long term durability isn't going to be an issue. Current designs are so large not because of stress, but rather due to a carry over of 100+ years of manufacturing necessity. My design overcomes the "problems" of doing a simple front locking rimfire without increasing manufacturing cost or affecting magazine feed. In fact, the cost may even be less in the long term. I can't explain too much of what is different as patents are still being examined and I don't want to throw away the $100k+ that I have spent so far by blabbing too much.
The CZ range of centrefires is a good example of scaling to fit a cartridge. Imagine for a minute that there existed a centrefire cartridge with the same dimensions as the 22lr. Would CZ make a new design, or just scale the 527 down even more??