One of the major "benefits" of the 22/45 is the 1911 set-up. But when I handled one, the safety was in the same place, but felt nothing like a 1911. You have to kind of squish your thumb into the button to toggle the safety.
I ended up with a Buck Mark, which I love. But the safety on it is pretty lame, too. I can barely operate it with several fingers, much less just my thumb. I don't need a safety on a .22, though. I'm not carrying it, just shootin' stuff for fun.
.45acp, .40 S&W, 9mm, .38 Spl, .380 acp, 22lr
12 gauge, .223/5.56x45mm, 30-30 Winchester
2 Chron. 7:14 Christians must seek His face