Location: Third bunker on the right,Central Virginia
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I use them in a Colt revolver for snakes- the .22 Magnum shot loads work better (and my .38 shot handloads MUCH better). They have sharply limited range- most of the 22s are #12 shot (dern near lead dust) and rifling puts a spin on the shot that makes pattern open up. I keep it to about 5 yards.
The will not cycle in a Ruger 10/22, and probably will have cycle issues in other auto loaders. Used them in a Taurus Tracker with a 6.5" barrel- not very effective beyond eight feet. Probably will get better range and effectiveness with a rifle.
They are fine for small birds and mice at very close range. They use #12 shot, which is called "dust shot" for a reason. When fired from a rifle, the rifling spins the shot which causes it to disperse rapidly. Effective range is roughly 10 feet. If you use a 22 smoothbore, range is somewhat greater.