I'm left handed and all my rifles are not. I've ywe3t to have a problem with any of them. I do switch out from time to time but that's just something I like to do. I have a couple Ruger 10-22's An AMT copy of the 10-22 and I shoot the crap out of them. It's all a matter o9f what you want from the rifle. The Marlin's are nice and you are hard pressed top go wrong with a Ruger. The glut of after market stuff is everywhere and reasonable for the most part. So it's not hard to recreate the rifle in just about any way you want. I do have a left handed Raptor stock
on one. It does making shooting left handed a breeze.
A 22 is a great weapon to cut ones teeth on as well as the experienced shooter. Ammo is cheap and plentiful and a decent rifle can be had really inexpensive as well. 550 rounds for 15 bucks and you cna get a Marlin 60 or 10-22 really cheap if you look around. I picked up one with a cheap scope at a pawn shop for 90 bucks a short time ago. That rifle as is will hit walnuts at 100 yards all day long with bulk ammo
Look around and keep your options open. You'll run into something you just can't live without many times that way. I trol through gun shows, pawn shops and gun shops all the time with no real goal in mind nad will sometimes fall bass akward into a great deal. That's how I found that AMT and it was just under a hundred bucks. And it's actually a better built rifle than the Ruger. Too bad they copied a little too close and got sued
Even had a Ruger mag in it (Insert LOL here). I do like the SS receivers in those as well as the longer barrels. THey are great to build on.