I've taken a 220 lb mule deer with a 55 gr from the mini 14 I used to have. That sucker didn't take 2 steps. Not a round I rue comment hunting with, but if you are proficient you can use what you want. I typically use my Remington 700 in .308. I am about to have in all of my parts and assemble my first 300 blackout. This will be my go to hog gun as well as short range deer slayer. In the brush country my longest shot may only be 150-200 yards, so my .308 is not necessary.
Here's a comparison of the difference in case/bullet size between 5.56 and 300 blackout. The 5.56 is a 62 gr ss109 and the .30 cal is a 168 gr Sierra Match King. I hand load all my .308's and am working on my 300 AAC Blackouts right now.
"No free man shall ever be debarred the use of arms. The strongest reason for the people to retain the right to keep and bear arms is, as a last resort, to protect themselves against tyranny in government"
-- Thomas Jefferson, 1 Thomas Jefferson Papers, 334