Sure! DPMS makes some and you might be able to find other manufacturers that also offer them.
Traditionally, the AR-15 and similar fire NATO 5.56mm which is very similar to Remington .223. The AR-10 fires a 7.62x51 (.308) round which might be more to your liking. It is functionally similar to the AR15 but heavier, of course.
I have a both a Stag Arms in 5.56 / .233 and a Barrett in 6.8. The 6.8 is awesome but it's hard to find ammo for and it's expensive when you do find it. The ballistics on the 6.8 are outstanding though! It has great knock down power and superior accuracy to that of the 5.56 / .223.