the 280 Remington is one of my favorites. excellent ballistics. i don't seem to find a lot of factory ammo in my area for this 280, but since i reload and there is an ample selection of 7mm bullets on the market, it's an easy one to reload.
really i find the ballistics much better than the 270 Win. and getting close to the 7mm Rem. Mag. without the recoil of a magnum cartridge.
like the 30-06 and 270, i doubt there are many game animals that couldn't be taken in North America with the 280 if one used proper shot placement and the correct ammo.