I am a big .25-06 fan. The first rifle I ever owned was a Savage 110C .270. When I shot the barrel out of it, I had a .25 barrel made by an ornery, one-eyed barrel maker who is a legend in these parts and then chambered it to .25-06. The first group I ever shot with it, after some careful break-in, went 0.16". A fellow I knew who was shooting a few stalls down heard the loud exclamations and asked me what was the matter.
I was so excited I'd forgotten all the words with more than two syllables.
Anyway, I've dropped big mule deer with it and whitetails. If I wasn't so fond of a custom 7mm Mag, I'd have no hesitation taking it elk hunting, either. I haven't seen or heard of an animal that died from hearing a big noise yet, but I do know of some who were hit badly by a small man shooting a fire breathing nitro magnum hell raiser and that crawled off to die somewhere.
My daughter shot her first WT buck with that .25-06, too. Blew the heart right out of it. It went about 3ft. after she hit it - straight down.
Yup, absolutely love this caliber. And yes, I do handload for it.