External Ballistics Calculator
That link will take you to a External Ballistice calculator to give you the trajectory of your load granted you need to know the information.
As far as sight in sight in for what ever range you want.
My varmint rifle it sighted in 2" high at 100 yards. With that I can hold dead on out two 250 yards and get a hit. It is all just knowing how you want to shoot.