the 280 Rem. is a very good cartridge. a 30-06 necked down to 7mm. IMO, one of the best offspring of the 30-06! suprisingly, it even has better ballistics than the 270 Win. and like others have said, getting pretty close to the 7mm Rem. Mag. if it can be hunted and killed with a 270, then the 280 will have not one bit of problem as long as shot placement and bullet selection is adhered to.
my older, Ruger M77V in 280 Rem. (made in 1979) will group 5 shots in less than .5" at 100 yards with my reloads. with premium factory ammo it will group easily about the same.