The 22-250 is an excellent caliber selection for varmint hunting. I recently bought a Howa 1500 in 270 Winchester caliber with a Leupold 3X9 Scope on it at a sale. I used it in Texas this year. It is a fine rifle and also has an adjustable trigger inside. Mine had just a slight bit of creep which most would not even notice. So it was easy to adjust and eliminate the creep. Would make you a fine rifle.
Howa made a version of this rifle for both Weatherby and Smith and Wesson also.
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The black sporter is my Ranchland 1500 in .22-250 and she's a sweet shooter. Get that trigger adjusted just so and it'll give you sub MOA all day long. My 250 loves 50 grain Hornady V-Max's.
The same goes for the heavy stainless beast. That's a 1500 varminter in .223. It'll give me sub MOA 5 shot groups all day long as well. Shot my best ever group with it, a .217" 5 shot clover leaf with 55 grain Hornady V-Max factory loads no less.
Imagine how well they will shoot when I start to hand load.
Another reason I really like my Howas, as one of the previous members posted, is the adjustable triggers. Sooooo easy to set. I have both of mine set to break at a nice crisp 2.5 lbs with absolutely NO creep.