For targets any round can be used for long range shooting. The old .45-70 was used for 1,000 yrd. matches for years. If your talking about hunt that a hole other ball game and I don`t think anyone should be shooting a big game at 1,000 yrds. I have a .22-6mm that I built for a long range coyote gun and it shoots flatter than any factory round but in the 25 yrds. between 625 and 650 the bullet will drop 6 in. with the loads I am currently useing. That boils down to if I`m off 25 yrds. on my range estimation, I miss. I have shot a 2 in group at 600 yrds. with the gun over the hood of my pick-up and have total faith in it, as long as I can get them ranged.