I prefer the steel framed Rugers with the pronounced grip angle. The newer 22/45 polymers just feel odd to me even though I do love the feel of a 1911. No doubt my preference was shaped by the first three pistols I bought, a P08 Luger, Ruger Mark I Target and Colt 1911. Lots of folks like the 22/45 so handle them both and choose the one you like best.
Don't forget that there are other fine .22lr pistols, even near clones of the 1911.
The biggest issue with assembling an AR isn't so much getting the parts together right - it's getting the right parts together.
US Army 1966-69, VFW Life Member, Retired Geek