Saw this thread so I thought I'd post my experience with these...
First mod should be a MKIII hammer bushing like this one: https://www.tandemkross.com/Steel-Ruger-Mark-III-2245-Magazine-Disconnect-Bushing_p_9.html
(use code RFQUALITY for 1.99 off) Also check out the Tandemkross Plus1 magazine bumpers that they offer here: https://www.tandemkross.com/2245-Plus1-Magazine-Bumpers_p_12.html
Second, a Volquartsen sear found here with free shipping: Rimfire Sports & Custom: Volquartsen Ruger Mark II / III & 22/45 Target Sear
No need to buy the whole Volquartsen kit if you have a 22/45 you guys. Its a waste of money. You only need the sear, and trigger if you want it. Everything else doesn't work or isn't needed for 22/45's. The hammer you have in your gun performs just as well as the VQ one.
Do those two things and you'll have a 2lb trigger pull that is just out of this world. Add a VQ trigger for pre and over travel screw settings if you want and you're good to go.